Toxicological risk assessment.


Advisory tasks with respect to toxic risk evaluation for both man and environment is an important additional task. This work is done for government, industrial partners as well as environmental and consumer organizations

The research topics under this theme are as follows:
                

-                      Development of a computational chemistry-based QSAR approach for setting research priorities in toxicity testing of nitrobenzenes on the EINECS list.

PhD:  E. Zvinavashe, promotion 2008; 

SP: I.M.C.M. Rietjens, A.J. Murk, A. Freidig (TNO), J. Vervoort (Biochemistry, WU)

 

-                      New PBPK based concepts for low-dose cancer risk extrapolation.

PhD: A. Punt, promotion 2008; SP: I.M.C.M. Rietjens, P.J. van Bladeren (Nestle)

 

-           Assessment of the toxicity of dredged sediments using the ‘Chemie-Toxiciteit-Toets’  (CTT) approach.

SP: AJ Murk, C Schipper and I.M.C.M. Rietjens

 

-           Ecotoxicological risk assessment for compounds in the marine and fresh water environment.

Several projects are available, e.g. including modeling, ecotoxicological tests, policy aspects. Location: IMARES (Den Helder or IJmuiden)

SP: AJ Murk and senior scientists from IMARES

 

-           Implementation and validation of integrated in vitro-in silico models for predicting human repeated dose toxicity; facilitating non-animal based safety assessments of chemicals

PhD: J. Louisse

SP: I.M.C.M. Rietjens, Han van de Sandt, Miriam Verwei, Cyrille Krul, Bas Blaauboer

 

-           Low Dose Mechanism of Action of Naturally Occurring, Genotoxic Carcinogens and Implications for Cancer Risk Assessment

PhD. A. Paini

SP (at Nestle lausanne Switerland) G. Scholz, B. Schilter, P.v. Bladeren, I.M.C.M. Rietjens

 


Please send remarks and questions about this website to: Tinka.Murk@WUR.nl



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