Toxicological evaluation of this rapidly emerging field is complex because it involves the effect of mixtures and interactions of components with the food matrix. New biochemical, cell- and molecular research strategies are required and developed, with emphasis on mechanisms of toxic effects.
The research topics under this theme are as follows:
- Modulation and modelling of flavonoid bioavailability at the level of their intestinal metabolism and transport.
PhD: W. Brand, promotion 2009;
SP: I.M.C.M. Rietjens, P.J. van Bladeren and G.Williamson (Nestle)
- System biology approach to enterohepatic circulation of cholesterol and bile acids.
PhD: N. v.d. Pas, promotion 2011; SP: R.Woutersen (TNO), A. Freidig (TNO), B.van Ommen (TNO), I.M.C.M. Rietjens
- Development and hazard assessment of new food technology-based nanoparticles.
PhD: promotion 2012
SP: G.M. Alink, L. de Haan, T. Marcelis (OC), I.M.C.M. Rietjens
- Risk-benefit analysis of natural constituents in rosemary.
SP: I.M.C.M. Rietjens, L. de Haan, J.J.M.J.J. Aarts
- Role of species differences and matrix effects in the toxicity of genotoxic carcinogenic alkenylbenzenes (methyleugenol, elemicin, safrole, estragole and myristicin) from herbs
SP: M. Boersma, I.M.C.M. Rietjens